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发布时间:2022-03-30      作者:    点击:[]    分享到:

必赢bwin网页版官网 生命科学与医学部 副教授


教育经历

2009/09-2013/06,北京大学,基础医学院,神经生物学系,理学博士

2004/09-2009/06,北京大学,基础医学院,医学学士


科研与学术工作经历

2019/3-至今, 必赢bwin网页版官网, 必赢bwin网页版官网, 副教授

2019/10-2020/12, 马萨诸塞州立大学, 食品科学系, 访问学者

2013/7-2019/3, 必赢bwin网页版官网, 必赢bwin网页版官网, 讲师


主要研究方向:研究食物及环境因素对结直肠癌发生发展的影响。通过基因组学数据分析与糖组学技术研究营养与结肠癌的关系。通过研究结直肠癌发病的分子机制寻找遗传标志物,为结直肠癌的早期筛查,精准治疗和预后诊断奠定基础。


联系方式:leilei@nwu.edu.cn


承担的科研项目

2022 陕西省科技厅面上项目(2022JM-522)

2019 陕西省科技厅青年项目(2019JQ-538)

2018 西部资源生物与现代生物技术教育部重点实验室开放基金

2018 陕西省教育厅青年项目(18JK0796)

2015 国家自然科学基金青年基金项目(31401081)


发表科研论文

1. Lei Lei#, Yi Wang#, Rui Liu, Jingjing Feng, Juan Tang, Junjie Gou, Feng Guan, Xiang Li*; Transfer of miR-4755-5p through extracellular vesicles and particles induces decitabine resistance in recipient cells by targeting CDKN2B, Molecular Carcinogenesis, 2023 (SCI 文章 IF 5.1)

2. Lei Lei, Qing Cao, Guoyan An, Yuejiao Lv, Juan Tang, Jin Yang*; DDI2 promotes tumor metastasis and resists antineoplastic, Apoptosis, 2022 (SCI 文章 IF 5.5)

3. Xin He, Feng Guan, Lei Lei*; Structure and function of glycosphingolipids on small extracellular vesicles, Glycoconjugate Journal, 2022 (SCI 文章 IF 2.9)

4. Lei Lei; Jun Yang; Jianan Zhang; Guodong Zhang*; The lipid peroxidation product EKODE exacerbates colonic inammation and colon tumorigenesis, Redox Biology, 2021, 101880: 2213-2317. (SCI 文章 IF 11)

5. Lei Lei; Jianan Zhang; Eric A. Decker; Guodong Zhang*; Roles of Lipid Peroxidation-Derived Electrophiles in Pathogenesis of Colonic Inflammation and Colon Cancer, Frontiers in Cell and Developmental Biology, 2021, 2021(9): 665591. (SCI 文章 IF 6.7)

6. Shuzhen Liu; Guoyan An; Qing Cao; Tong Li; Xinyu Jia; Lei Lei*; The miR-106b/NR2F2-AS1/PLEKHO2 Axis Regulates Migration and Invasion of Colorectal Cancer through the MAPK Pathway, International Journal of Molecular Sciences, 2021, 2021(22): 5877. (SCI 文章 IF 5.9)

7. Shuzhen Liu; Qing Cao; Guoyan An; Bianbian Yan; Lei Lei*; Identification of the 3-lncRNA Signature as a Prognostic Biomarker for Colorectal Cancer, International Journal of Molecular Sciences, 2020, 2020(21): 9359. (SCI 文章 IF 5.9)

8. Qing Cao#; Zewen Dong#; Shuzhen Liu; Guoyan An; Bianbian Yan; Lei Lei*; Construction of a metastasis-associated ceRNA network reveals a prognostic signature in lung cancer, Cancer Cell Int, 2020, (2020) 20:208. (SCI 文章 IF 5.7)

9. Lei Lei*; Guoyan An; Ziqing Zhu; Shuzhen Liu; Yutong Fu; Xiaonan Zeng; Qing Cao; Bianbian Yan; C8orf48 inhibits the tumorigenesis of colorectal cancer by regulating the MAPK signaling pathway, Life Sciences, 2020, 266(2021): 0-118872. (SCI 文章 IF 5)

10. Lei Lei; Xiaojuan Zhao; Shuzhen Liu; Qing Cao; Bianbian Yan; Jin Yang*; MicroRNA-3607 inhibits the tumorigenesis of colorectal cancer by targeting DDI2 and regulating the DNA damage repair pathway, Apoptosis, 2019, 24(7-8): 662-672. (SCI 文章 IF 4.7)

11. Hongjuan He; Xiaojuan Zhao; Ziqing Zhu; Le Du; Erfei Chen; Shuzhen Liu; Qiqi Li; Jing Dong; Jin Yang; Lei Lei*; MicroRNA-3191 promotes migration and invasion by downregulating TGFBR2 in colorectal cancer, Journal of Biochemical and Molecular Toxicology, 2019, 33(6): 0-e22308. (SCI 文章 IF 3.6)

12. Hongjuan He#, Lei Lei#, Erfei Chen, Xiaona Xu, Lili Wang, Junqiang Pan, Fangfang Yang, Min Wang, Jing Dong, Jin Yang* The screening of the functional microRNA binding site SNPs in sporadic colorectal cancer genes. Cancer Biology & Therapy ISSN: 1538-4047 April 23 2017(并列一作,SCI文章 IF 4.7)

13. Lei Lei, Xu Cao, Fan Yang, Di-Jing Shi, Yi-Quan Tang, Jie Zheng and KeWei Wang*; A TRPV4 Channel C-Terminal Folding Recognition Domain Critical For Trafficking And Function, Journal of Biological Chemistry, VOL.288 NO.15, pp.10427-10439, April 12, 2013(SCI 文章 IF 5.1)

14. 赵晓娟 杨莹 雷蕾* 黏蛋白在结直肠癌中的表达及基因调控, 基因组及应用生物学,2017年,第36卷,第1期,第1-8页

15. 贺红娟 陈尔飞 雷蕾* 肿瘤发生与相关基因突变的关联,基因组及应用生物学,2015年,第34卷,第1期,第208-214页