个人简介

王会娟，2011年获得必赢bwin网页版官网生物化学与分子生物学博士学位，自2011年至今于必赢bwin网页版官网生物技术系任教，硕士生导师，国家微检测系统工程技术研究中心研发中心主任，中国药理学会药物基因组学专业委员会副秘书长。2016年度陕西省青年科技新星。
通信地址：陕西省西安市太白北路229号必赢bwin网页版官网国微中心，邮编：710069
Email: whj@nwu.edu.cn
电话: +86 (0)29-88303446-822

主要研究方向
研究方向一：药物基因组学，主要包括多态性CYP450体外功能研究、抗肿瘤药物基因型-表型研究、肿瘤耐药机制研究、基因检测技术的开发及临床基因检测产品的开发和应用。
研究方向二：疾病的分子致病机制研究，主要采用多组学技术对单基因遗传病（如先天性甲减，苯丙酮尿症）或复杂疾病（如子痫前期）的致病基因和分子致病机制进行研究。

承担的科研项目

在研项目
1. 国家自然科学基金青年科学基金项目，81702483，蝎形引物结合数字PCR技术检测脑脊液ctDNA突变新方法及其临床应用研究，2018/01-2020/12, 20万元，在研，主持。
2. 陕西省创新人才推进计划-青年科技新星项目，2017KJXX-33，脑胶质瘤无创循环肿瘤DNA检测新技术的开发和应用研究,2017/08-2019/12，10万元，在研，主持
3. 国家重点研发计划精准医学专项，2016YFC0905002，药物遗传标记物的临床评价与精准用药方案，2016/07-2018/12, 30万元，在研，子课题负责人
4. 国家博士后自然科学基金，2015M582695，Notch1活化在BRAF抑制剂耐药中的作用及分子机制研究，2016/01-2017/12，5万元，在研，主持
5. 陕西省教育厅科研专项，2013JK0712，IDH1基因突变在肿瘤发生和治疗中的作用研究，2013/07-2015/06，2万元，已结题，主持
6. 国家高技术研究发展计划（863计划），2012AA02A519，个体化用药关键技术及相关产品研发，2012/01-2015/12，1080万元，已结题，参加（第三完成人）
7. 重大新药创制，2012ZX09506001-007，药物代谢酶基因多态性与药物安全性和有效性关系检测技术的建立及其在新药开发中的应用， 2012/01-2015/12， 514.65万元，已结题，参加（第三完成人）

主要研究成果

已授权发明专利
1. 一种基于实时荧光PCR检测HLA-B*5801等位基因的方法. ZL201410503857.X. 康星, 王会娟, 陈融　刘金辉, 戴鹏高, 陈超. 2017.02.15
2. 一种检测HLA-B*5801等位基因的TaqMan探针实时荧光PCR方法. ZL201410503583.X. 康星, 王会娟, 陈融　刘金辉, 戴鹏高, 陈超. 2017.04.19
3. 一种检测HLA-B*13:01等位基因的多重实时荧光PCR方法. ZL201510412967.5. 刘正斌, 王会娟, 康星，韩敏，陈融, 周少荷, 陈超.2018.02.06
4. 一种检测HLA-B*15:02等位基因的多重实时荧光PCR方法. ZL20151023655.0. 王会娟, 康星，陈融, 刘正斌，韩敏，周少荷, 陈超。2018.04.06
代表性论文
1. Xi Chen, Xiaohong Kong, Jie Zhu, Tingting Zhang, Yanwei Li, Guifeng Ding*, Huijuan Wang,* Mutational Spectrum Analysis of Seven Genes Associated with Thyroid Dyshormonogenesis. International Journal of Endocrinology. 2018, doi.org/10.1155/2018/8986475.
2. Xing Kang, Hailong Shi, Lirong Zhang, Yanxia Wang, Tingting Zhang, Min Han, Chao Chen*, Huijuan Wang*, Genetic Polymorphisms of CYP2S1, CYP2J2, and CYP2R1 Genes in Three Chinese Populations: Han, Tibetan, and Uighur. Pharmacogenomics. Pharmacogenomics. 2018 Aug 1;19(12):961-977.
3. Tingting Zhang, YingXiao, Xing Kang, Yanwei Li, Yanxia Wang, Chao Chen*, Huijuan Wang*. Single-tube multiplex real-time PCR assay for rapid and reliable detection of HLA-A*31:01 allele. Pharmacogenomics, 2018 Jul 1;19(10):837-846.
4. Huijuan Wang, Xing Kanga, Rong Chen, Min Han, Zhengbin Liu, Xuyun Liu, Chao Chen* and Yongkuan Gong*. Rapid and reliable screening of HLA-B*15:02 in four Chinese populations using a single-tube multiplex real-time PCR assay. Pharmacogenomics, doi.org/10.2217/pgs-2017-0041
5. Min Han, Xing Kang, Zhengbin Liu, Tingting Zhang, Yanwei Li, Chao Chen, Huijuan Wang,* Rapid and reliable genotyping of HLA-B*57:01 in four Chinese populations using a single-tube duplex real-time PCR assay. AIDS Res Hum Retroviruses. 2017 Jul;33(7):711-717..IF=1.949
6. Zhang J, Yang JH, Quan J, Kang X, Wang HJ, Dai PG, Identification of MGMT promoter methylation sites correlating with gene expression and IDH1 mutation in gliomas. Tumor Biol. 2016 Jul 28. DOI: 10.1007/s13277-016-5153-4
7. Jiao W, Xun X, Liu J, Yang J, Wang Q, Wang L, Chen C, Wang H, Dai P.  Diagnostic significance of suppressor of cytokine signalling 3 (SOCS3) methylation and  its correlation with IDH1 mutation in Chinese glioma patients. Biomarkers. 2016 Jul 21:1-6.
8. Liu Z, Chen G, KangX, Han M, Chen R, Chen C, Wang H*. A multiplex allele-specific real-time polymerase chain reaction assay for HLA-B*13:01 genotyping in four Chinese populations. HLA. 2016; 88(4):164-171. doi: 10.1111/tan.12863
9. Yanwei Li, Xing Kang, Ge Yang, Penggao Dai, Chao Chen, and Huijuan Wang*. Identification of genetic polymorphisms of CYP2W1 in the three main Chinese ethnicities: Han, Tibetan, and Uighur. Drug Metab Dispos, 2016，44(9):1510-5.
10. Huijuan Wang, Hua Yang,Tian Feng, Tingting Geng, Chao Chen, Tianbo Jin. Effects of TERT gene polymorphism and environmental factor interactions on lung cancer risk in the Xi’an Han population, Int J Clin Exp Med 2016;9(2):4200-4210.(1.27)
11. Kang Xing, Chen Rong, Han Min, Liu Zhengbin, Liu Jinhui, Dai Penggao, Chen Chen, Wang Huijuan*. Rapid and reliable genotyping of HLA-B*58:01 in four Chinese  populations  using a single-tube duplex real-timePCR assay. Pharmacogenomics. 2016 Jan;17(1):47-57. (IF:3.218)
12. Xing Kang, Rong Chen, Jie Zhang, Gang Li, PengGao Dai, Chao Chen, Huijuan Wang*. Expression Profile Analysis of Zinc Transporters (ZIP4, ZIP9, ZIP11, ZnT9) in Gliomas and Their Correlation with IDH1 Mutation Status. Asian Pac J Cancer Prev. 2015; 16(8):3355-3360.
13. Wenjing Zhou, Tingting Geng,  Huijuan Wang,  Xiaojie Xun, Tian Feng, Hui Zou, Longli Kang,
Tianbo Jin, Chao Chen. CHRNA3 genetic polymorphism and the risk of lung cancer in the Chinese Han smoking population. Tumor Biol. 2015;36(7): 4987-4992.
14. Huijuan Wang, Bobo Yang, Tingting Geng, Bin Li, Penggao Dai, Tianbo Jin, Chao Chen. Tissue-specific selection of optimal reference genes for expression analysis of anti-cancer drug-related genes in tumor samples using quantitative real-time RT-PCR. Experimental and Molecular Pathology. 2015,98 (3): 375–381.
15. Xiaojie Xun, Huijuan Wang, Hua Yang, Hong Wang, Bo Wang, Longli Kang, Tianbo Jin, Chao Chen. CLPTM1L Genetic Polymorphisms and Interaction With Smoking and Alcohol Drinking in Lung Cancer Risk. Medicine (Baltimore). 2014 Dec;93(28):e289. (Co-first author)
16. Huijuan Wang,  Ting Bian, Tianbo Jin, Yong Chen, Aifen Lin, Chao Chen, Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers, Pharmacogenomics, 2014, 15(6):789-798.
17. Peng Xia, Huijuan Wang, Tingting Geng, Xiaojie Xun, Wenjing Zhou, Tianbo Jin, Chao Chen*, Mitochondrial DNA Levels in Blood and Tissue Samples from Breast Cancer Patients of Different Stages, Asian Pac J Cancer Prev, 2014;15(3):1339-44.(Co-first author)
18. Huijuan Wang, Ting Bian, Duan Liu, Tianbo Jin, Yong Chen, Aifen Lin, Chao Chen*, Association analysis of CYP2A6 genotypes and haplotypes with 5-fluorouracil formation from tegafur in human liver microsomes, Pharmacogenomics, 2011, 12(4): 481-92.
19. Huijuan Wang, Nianzhen An, Hao Wang, Yiwen Gao, Duan Liu, Ting Bian, Juanli Zhu, Chao Chen*, Evaluation of the effects of 20 non-synonymous Single-nucleotide polymorphisms of CYP2C19 on S-Mephenytoin 4’-hydroxylation and Omeprazole 5’-hydroxylation, Drug Metab Dispos, 2011,39(5):830-7.
20. Huijuan Wang, Raymond Kim, Dongxu Sun, Yiwen Gao, Hao Wang, Juanli Zhu, Chao Chen*, Evaluation of the effects of eighteen non-synonymous single-nucleotide polymorphisms of CYP450 2C19 on in vitro drug inhibition potential by a fluorescence-based high-throughput assay, Xenobiotica, 2011, 41(9):826-35.
21. Huijuan Wang, Yiwen Gao, Pingping Ma, Juanli Zhu, Chao Chen*, Expression and functional analysis of human cytochrome 2C19 polymorphic alleles, Drug Metabolism Reviews, 2009,41:s1[Abstract].
22. Duan Liu, Gao Y, Huijuan Wang, Jing Zi, Juanli Zhu, Chao Chen*, Evaluation of the Effects of Cytochrome P450 Non-synonymous Single-nucleotide Polymorphisms on DBZ Metabolism and Inhibition Potential, Drug Metab Dispos, 2010, 38(12):2259-65.
23. Yiwen Gao, Duan Liu, Huijuan Wang, Juanli Zhu, Chao Chen*, Functional characterization of five CYP2C8 variants and prediction of CYP2C8 genotype-dependent effects on in vitro and in vivo drug-drug interactions, Xenobiotica, 2010,40(7), 467-75.

获得的教学和科研表彰

成果奖
1. 2017, 药物个性化筛选和精准治疗关键技术研究, 陕西省科学技术奖一等奖，陈超、戴鹏高、王会娟、刘金辉、段降龙、颜桦、王浩、李刚、耿婷婷、邹晖
2. 2016, 肿瘤个体化用药关键技术的研究与应用，陕西高校科学技术奖励一等奖，陈超，王会娟，戴鹏高，刘金辉，王博，邹晖，王浩