个人简介
李倩,副教授,硕士生导师。本、硕、博及博士后就读于必赢bwin网页版官网,2018年师资博士后出站,选聘为讲师,2018年2月至2020年1月在美国普渡大学访学。近年来,主要致力于中药功效物质分析技术创建及应用。主持国家自然科学基金项目2项,中国博士后基金面上项目1项,必赢bwin网页版官网“青年学术英才支持计划”项目1项;获陕西省科学技术进步奖一等奖1项,陕西省科学技术奖二等奖1项,陕西高等学校科学技术奖一等奖2项;授权中国发明专利2项,形成软件著作权1项。
教育经历
1. 2013/09-2016/06,必赢bwin网页版官网,必赢bwin网页版官网,中药学系,博士
2. 2010/09-2013/07,必赢bwin网页版官网,必赢bwin网页版官网,中药学系,硕士
3. 2006/09-2010/07,必赢bwin网页版官网,必赢bwin网页版官网,生物技术系,学士
工作经历
1. 2020/10-至今,必赢bwin网页版官网,必赢bwin网页版官网,副教授
2. 2018/02-2020/01,美国普渡大学,化学系,访问学者
3. 2018/11-2020/09,必赢bwin网页版官网,必赢bwin网页版官网,讲师
4. 2016/07-2018/10,必赢bwin网页版官网,必赢bwin网页版官网,师资博士后
承担的科研项目
1. 国家自然科学基金面上项目,22074118,复杂样品干扰物质在线去除与手性药物同步分离制备受体色谱方法的建立及应用,2021/01-2024/12,主持。
2. 国家自然科学基金青年项目,21705126,内皮素受体A-药物相互作用快速分析受体色谱方法的建立与评价,2018/01-2020/12,主持。
3. 中国博士后科学基金面上项目,2017M620467,内皮素受体色谱靶向筛选四物汤活性成分,2018/01-2019/12,主持。
4. 必赢bwin网页版官网青年学术英才支持计划,2019/01-2022/12,主持。
主要科研成果
(一)发表文章
1. Qian Li, Longfei Liu, Dake Mao, Yuyan Yu, Weili Li, Xinfeng Zhao, Chengde Mao. ATP-triggered, allosteric self-assmbly of DNA nanostructures, Journal of the American Chemical Society, 2020, 142, 665-668.
2. Qian Li, Xiaohui Ning, Yuxin An, Brett J Stanley, Yuan Liang, Jing Wang, Kaizhu Zeng, Fuhuan Fei, Ting Liu, Huanmei Sun, Jiajun Liu, Xinfeng Zhao, Xiaohui Zheng. Reliable analysis of the interaction between specific ligands and immobilized beta-2-adrenoceptor by adsorption energy distribution [J]. Analytical Chemistry. 2018, 90(13): 7903-7911.
3. Kaizhu Zeng, Qian Li, Jing Wang, Guowei Yin, Yajun Zhang, Chaoni Xiao, Taiping Fan, Xinfeng Zhao, Xiaohui Zheng. One-step methodology for the direct covalent capture of GPCRs from complex matrices onto solid surfaces based on the bioorthogonal reaction between haloalkane dehalogenase and chloroalkanes [J] Chemical Science, 2017, 9(2): 446-456 (共同第一).
4. Qian Li, Pan Qiao, Xiu Chen, Jing Wang, Liujiao Bian, Xiaohui Zheng. Affinity chromatographic methodologies based on immobilized voltage dependent anion channel isoform 1 and application in protein-ligand interaction analysis and bioactive compounds screening from traditional medicine [J]. Journal of Chromatography A, 2017: 1495, 31-45.
5. Qian Li, Shuaihua Li, Xiu Chen, Liujiao Bian. A G-quadruplex based fluorescent oligonucleotide turn-on probe towards iodides detection in real samples [J]. Food Chemistry, 2017, 230: 432-440.
6. Qian Li, Tianlong Zhang, Liujiao Bian. Recognition and binding of β-lactam antibiotics to bovine serum albumin by frontal affinity chromatography in combination with spectroscopy and molecular docking [J]. Journal of Chromatography B, 2016, 1014: 90-101.
7. Qian Li, Meijiao Duan, Shasha Li, Yeli Zhang, Pan Qiao, Liujiao Bian. Recognition and binding of voltage-dependent anion channel-1 with ATP and NADH by spectroscopic analysis and molecular docking [J]. RSC Advances, 2016, 6: 13407-13417.
8. Qian Li, Jing Wang, Guangxin Liu, Huanmei Sun, Liujiao Bian, Xinfeng Zhao, Xiaohui Zheng. Screening bioactive compounds from Ligusticum chuanxiong by high density immobilized human umbilical vein endothelial cells [J]. Analytical and Bioanalytical Chemistry, 2015, 407: 5783-5792.
9. Qian Li, Jing Wang, Yuqing Yuan Zheng, Lingjian Yang, Yajun Zhang, Liujiao Bian, Jianbin Zheng, Zijian Li, Xinfeng Zhao, Youyi Zhang. Comparison of zonal elution and nonlinear chromatography in determination of the interaction between seven drugs and immobilized β2-adrenoceptor [J]. Journal of Chromatography A, 2015, 1401: 75-83.
10. Qian Li, Jing Wang, Lingjian Yang, Xiaokang Gao, Hongwei Chen, Xinfeng Zhao, Liujiao Bian, Xiaohui Zheng. Estimation of interaction between oriented immobilized green fluorescent protein and its antibody by high performance affinity chromatography and molecular docking [J]. Journal of Molecular Recognition. 2015, 28(7): 438-446.
11. Qian Li, Liujiao Bian, Xinfeng Zhao, Xiaokang Gao, Jianbin Zheng, Zijian Li, Youyi Zhang, Ru Jiang, Xiaohui Zheng. Immobilised histidine tagged β2-adrenoceptor oriented by a diazonium salt reaction and its application in exploring drug-protein interaction using ephedrine and pseudoephedrine as probes [J]. PLOS ONE, 2014, 9(4): e94955.
(二)申请专利
1. 赵新锋,王静,李倩,袁心怡. 中药活性成分靶向筛选方法及试剂盒,中国发明专利,202010803669.X,已受理
2. 赵新锋,李倩,王静. 止咳平喘中药活性成分靶向筛选方法及试剂盒,中国发明专利,202010803680.6,已受理
3. 赵新锋,李倩,王静,曾凯竹. 基于halo-tag特异性脱卤反应的蛋白质一步定向固定化方法,中国发明专利,202010802740.2,已受理
4. 赵新锋,常中满,张亚军,王静,李倩. 一种外用治疗痤疮的药物组合物及其制备方法,中国发明专利,202010983823.8,已受理
5. 赵新锋,郑晓晖,于洁,王世祥,李倩. 一种高密度RGD肽修饰材料的制备方法及应用,中国发明专利,2015101756383,2018/03/13,已授权
6. 边文海,李倩,陈秀,王超展,边六交. 一种快速止血剂,中国发明专利,201610996028.4,2018/02/13,已授权
(三)软件著作
1. 蛋白质-药物相互作用分析软件,软著登字第4292244号
(四)获得奖励
1. 2019年陕西省科学技术进步奖一等奖(郑晓晖,赵新锋,郑小璞,殷倩,李子健,白亚军,李倩,张亚军,廖莎,王静,张群正. 中药分子新药研发“合策略”的构建及基础应用,2019,第七完成人)
2. 2018年陕西省科学技术奖二等奖(高文运,边六交,李恒,李倩,赵新锋,张椰莉,刘慧. 几种具有重要生理功能的蛋白的制备、功能、作用机制及应用,2018,第四完成人)
3. 2017年陕西高等学校科学技术奖一等奖(李恒,李倩,边六交,高文运,赵新锋. 几种具有重要生理功能的蛋白的制备、功能、作用机制及应用,2017,第二完成人)
4. 2018年陕西高等学校科学技术奖一等奖(郑晓晖,赵新锋,贾璞,李倩,白亚军,肖超妮,张亚军,廖莎,边六交,郑小璞,郑建斌. 基于“良关系”的组合中药分子化学新药研发策略的构建及基础应用,2018,第四完成人)